Please note: We have no space to commit to other trainees at this time, and we are not accepting applications for Molecular or Cytogenetics fellowships for 2017,
2018, or 2019
Clinical Cytogenetics – Training in the Clinical Cytogenetics Laboratory will encompass all areas of
clinical cytogenetic techniques including traditional G‐banding of metaphase chromosomes, microscopic
analysis, computer assisted imaging and analysis, cell culture and cell harvest methods, slide‐making,
fluorescence in situ hybridization (FISH) methods and analysis for both metaphase cells and interphase
nuclei, microarray analysis, instrumentation monitoring, maintenance and operation, specimen
accessioning/documentation/chain of custody, quality control/quality assurance, data interpretation
and reporting. Application of these techniques will include specimens of all varieties including prenatal
(amniocyte and CVS specimens), postnatal specimens for newborn, adolescent and adult patients,
products of conception, and neoplastic samples (bone marrow aspirates, leukemic blood specimens,
core biopsies, lymph nodes, solid tumors, and formalin‐fixed, paraffin‐embedded tissue blocks).
Trainees will learn to identify cytogenetic aberrations by G‐banding, microarray and FISH technologies
and will be able to recognize disease associations for these aberrations.
Working with the Cytogenetics Training Director, the trainee will review interpretation of results
and sign out for cytogenetics cases and will discuss findings and clinical correlation(s) with referring
physicians and genetic counselors. Trainees will also participate in the laboratory’s quality assurance
program, assay development and validation, monthly laboratory meetings, and various on‐site or selfinspections
for CAP, JHACO, CMS, etc. to become familiar with regulatory issues in clinical cytogenetics.
Broader ethical and professionalism issues will also be introduced during interaction with the
Cytogenetics Training Director during case sign out.